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Ménétrier's disease
Ménétrier disease (also known as ''hypoproteinemic hypertrophic gastropathy''; named after a French physician Pierre Eugène Ménétrier, 1859–1935), is a rare, acquired, premalignant disease of the stomach characterized by massive gastric folds, excessive mucous production with resultant protein loss, and little or no acid production. The disorder is associated with excessive secretion of transforming growth factor alpha (TGF-α).〔Coffey RJ et al.: (Menetrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach ). J Clin Invest. 2007;117(1):70–80. doi:10.1172/JCI30491〕
==Signs and symptoms==
The mean age when signs and symptoms first appear is 30 to 60 years. Individuals with the disease present with upper abdominal pain, at times accompanied by nausea, vomiting, loss of appetite, and weight loss. Occult gastrointestinal bleed may occur, but overt bleeding is unusual and, when present, is due to superficial mucosal erosion. Twenty to 100% of patients, depending on time of presentation, develop a protein-losing gastropathy accompanied by low blood albumin and edema.〔Harrison's Principle of Internal Medicine, 18e, pg 2459〕
Symptoms and pathological features of Ménétrier disease in children are similar to those in adults, but disease in children is usually self-limited and often follows respiratory infection.〔Robbins and Cotran, Pathological Basis of Disease, 8e, pg 782〕
The risk of gastric adenocarcinoma is increased in adults with Ménétrier disease.〔〔Townsend et al., Sabiston Textbook of Surgery, 18e, pg 1272〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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